Excavating Anticonvulsant Compounds from

Excavating Anticonvulsant Compounds from

Comparison of the Anticonvulsant Activities of Substituted

Nov 29, 2020 · The anticonvulsant activity of hydroxycoumarin derivatives and 4-[(3-nitro-2-oxo-2H-chromen-4-yl)amino] butanoic acid was studied using nicotine and corazole convulsion models.All investigated compounds protected animals from death in of cases after intraperitoneal administration of the LD 50 of nicotine (14 mg/kg). 4-[(3-Nitro-2-oxo-2H …

Get a Quote

Medicinal compounds with antiepileptic/anticonvulsant

Excavating Anticonvulsant Compounds from Prescriptions of Traditional Chinese Medicine in the Treatment of Epilepsy. The American Journal of Chinese Medicine 2018, 46 (04), 707-737.

Get a Quote

Synthesis, anticonvulsant properties and 5-HT1A/5-HT2A

In addition, since the investigated compounds belong to a class of long-chain arylpiperazines, their serotonin 5-HT1A and 5-HT2A receptor affinity was determined. All the 2-OCH3 and 3-Cl derivatives were the most potent 5-HT1A receptor ligands (Ki = 24-143 and 70-107 nM, respectively), whereas the highest 5-HT2A affinity was observed for the

Get a Quote

Synthesis, anticonvulsant activity and QSAR studies of

May 28, 2016 · The compounds showed anticonvulsant activity exclusively against MES convulsions. The compounds were found especially active in 100 mg/kg dose at both the time points, i.e., 0.5 and 4 h, depending upon the lipophilicity of molecules as indicated by statistically significant reduction in the time spent in tonic extension phase (p < 0.001).

Get a Quote

ZA903021B - Anticonvulsant compounds - Google Patents

anticonvulsant compounds Prior art date Liming Application number ZA903021A Inventor James Leroy Kelley Leroy Kelley James Original Assignee Wellcome Found Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

Get a Quote

Anticonvulsant compounds from the wood of Caesalpinia

Aug 01, 2000 · Excavating Anticonvulsant Compounds from Prescriptions of Traditional Chinese Medicine in the Treatment of Epilepsy. Zhao Z, He X, Ma C, Wu S, Cuan Y, Sun Y, Bai Y, Huang L, Chen X, Gao T, Zheng X. Am J Chin Med, 46(4):707-737, 08 May 2018 Cited by: 6 articles | PMID: 29737210. Review

Get a Quote

Excavating Anticonvulsant Compounds from Prescriptions of

May 08, 2018 · Excavating Anticonvulsant Compounds from Prescriptions of Traditional Chinese Medicine in the Treatment of Epilepsy. Zefeng Zhao * Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an 710069, P. …

Get a Quote

Triazoline anticonvulsant compounds and compositions - The

I claim: 1. An anticonvulsant composition comprising as the active ingredient an anticonvulsive effective amount of a compound selected from the group consisting of those of the formulae: ##STR14## wherein R 1 is o-chlorophenyl, o-nitrophenyl, 2, 4- or 2,6-dichlorophenyl, or 2-quinolyl, and R 2 is hydrogen, m- or p-trifluoromethyl, p-methyl, p-ethyl, m- or p-chloro, m-nitro, p-bromo, …

Get a Quote

Excavating precursors from the traditional Chinese herb

Dec 02, 2013 · The active medicinal compounds that have shown anticonvulsant or antiepileptic activity were included and classified according to structural types. Results. We have reviewed herein the active constituents including alkaloids, flavonoids, terpenoids, saponins, and coumarins. The screening models, the seizures-inducing factors and response, the

Get a Quote

A REVIEW ON ANTICONVULSANT ACTIVITY OF 1, 3 …

Sep 01, 2013 · , 3-Benzodioxole ring system present in various naturally occurring molecules. Various synthetic molecules having 1, 3-Benzodioxole ring system have shown various biological activities. Stiripentol and Antiepilepserine are recently developed antiepileptic drugs which contain 1, 3-Benzodioxle rings system in core moiety. In the present work I have focused on the …

Get a Quote

Evaluation of extraction methods for pharmacologically

Feb 21, 2021 · The aim of the study was to evaluate methods for analyte extraction paired with a rapid instrumental analysis, DART-MS, for pharmacologically active compounds in anticonvulsant herbal medicines, Gou Teng, Tian Ma, and Jiang Can. Different extraction methods were selected for evaluation based on being quick, simple methods that could be easily

Get a Quote

ZA903021B - Anticonvulsant compounds - Google Patents

anticonvulsant compounds Prior art date Liming Application number ZA903021A Inventor James Leroy Kelley Leroy Kelley James Original Assignee Wellcome Found Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

Get a Quote

Identification of compounds with anti-convulsant

Identification of compounds with anticonvulsant activity in the zebrafish embryo. Previously unknown inhibitors of neural activity were identified within the Microsource Spectrum Collection, on the basis of their concentration-dependent suppression of PTZ-induced fos expression and inhibition of PTZ-induced locomotor activity.

Get a Quote

Excavating precursors from the traditional Chinese herb

This paper is intended to review the advances in the active anticonvulsant compounds isolated from herbs in the prescription of TCM in the treatment of epilepsy. These compounds were introduced with the details including classification, CAS number specific structure and druggability data. Meanwhile, much of the research in these compounds in the last two …

Get a Quote

Evaluation of extraction methods for pharmacologically

Oct 30, 2020 · The aim of the study was to evaluate methods for analyte extraction paired with a rapid instrumental analysis, DART-MS, for pharmacologically active compounds in anticonvulsant herbal medicines, Gou Teng, Tian Ma, and Jiang Can. Different extraction methods were selected for evaluation based on being quick, simple methods that could be easily

Get a Quote

The Role of Chinese Medicine in Health Maintenance and

Apr 26, 2019 · Excavating anticonvulsant compounds from prescriptions of traditional Chinese medicine in the treatment of epilepsy. Am. J. Chin. Med. 46: 707–737, 2018.

Get a Quote

Absence of side-effects in the anticonvulsant action of

The anatomical separation of anticonvulsant action and side-effects induced by these compounds suggests that this class of compounds may eventually be useful as antiepileptic drugs. KW - 2-amino-5-phosphonovalerate. KW - 3-hydroxy-2-quinoxalinecarboxylic acid. KW - anticonvulsant. KW - epilepsy. KW - γ-d-glutamylglycine

Get a Quote

Anti-seizure compounds found in CBGA - Blog-Cannabis

Oct 06, 2021 · A new Australian study examines the anticonvulsant effects of a number of rare compounds in cannabis. This new study reports that cannabigerolic acid (CBGA), informally called the "mother of all cannabinoids", may be more effective at …

Get a Quote

Uncovering the Pharmacological Mechanism of Chaibei

He, C. Ma et al., "Excavating anticonvulsant compounds from prescriptions of traditional chinese medicine in the treatment of epilepsy," American Journal of …

Get a Quote

Excavating precursors from the traditional Chinese herb

Excavating precursors from the traditional Chinese herb Polygala tenuifolia and Gastrodia elata: Synthesis, anticonvulsant activity evaluation of 3,4,5 28, 30 and 32 exhibited preferable anticonvulsant activity in primary evaluation, with compounds 28 and 32 being the most promising anticonvulsant agents in according to results of

Get a Quote
Copyright © Talenet Group all rights reserved